Preparation and quality by design assisted (Qb-d) optimization of bioceramic loaded microspheres for periodontal delivery of doxycycline hyclate
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چکیده
منابع مشابه
Isoniazid loaded chitosan microspheres for pulmonary delivery: Preparation and characterization
The objective of the present study was to entrap isoniazid, an Antitubercular drug, in cross linked chitosan matrix and study in vitro lung deposition of powdered chitosan microspheres using Andersen cascade impactor. Ionic cross linker Tripolyphospate was used to make cross linked chitosan microspheres to achieve sustained drug release. Chitosan microspheres were prepared by spray drying metho...
متن کاملFormulation optimization and characterization of spray dried microparticles for inhalation delivery of doxycycline hyclate.
The local delivery of antibiotics in the treatment of infectious respiratory diseases is an attractive alternative to deliver high concentration of antimicrobials directly to the lungs and minimize systemic side effects. In this study, inhalable microparticles containing doxycycline hyclate, sodium carboxymethylcellulose, leucine and lactose were prepared by spray drying of aqueous ethanol form...
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An Approach to the Design of a Particulate System for Oral Protein Delivery .II. Preparation and Stability Study of rhGH-Loaded Microspheres in Simulated Gastrointestinal Fluids
The delivery of therapeutic proteins has gained momentum with development of biotechnology. However, large molecular weight, hydrophilic nature and susceptibility to harsh environment of gastrointestinal tract (GIT) resulted in low absorption. The main objective of this work was the design of a particulate system for oral delivery of recombinant human growth hormone (rhGH) on the basis of parti...
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ژورنال
عنوان ژورنال: Saudi Journal of Biological Sciences
سال: 2021
ISSN: 1319-562X
DOI: 10.1016/j.sjbs.2021.03.046